Parkes S E, Muir K R, al Sheyyab M, Cameron A H, Pincott J R, Raafat F, Mann J R
West Midlands Regional Children's Tumour Research Group, Children's Hospital, Birmingham, UK.
Br J Surg. 1993 Apr;80(4):502-4. doi: 10.1002/bjs.1800800433.
Forty carcinoid tumours of the appendix were identified in children under 15 years of age between 1957 and 1986 from the records of the West Midlands Regional Children's Tumour Research Group. A significant excess of girls was observed (P = 0.02). All tumours were discovered incidentally and two patients underwent further surgery. Twenty-two of the 29 confirmed locations (76 per cent) were at the tip of the appendix and 34 of the 40 tumours (85 per cent) had invaded beyond the appendiceal submucosa. The reported incidence rate of 1.14 per million children per year remained constant throughout the study period. No recurrences, metastases or deaths from tumour were detected. Appendicectomy alone is confirmed as usually curative, although right hemicolectomy is occasionally necessary. Caution during routine appendicectomy is recommended to avoid possible tumour damage, as is consistent histological examination of all appendices in the paediatric age group. The importance of long-term follow-up is emphasized.
1957年至1986年间，从西米德兰兹地区儿童肿瘤研究小组的记录中，确认了15岁以下儿童的40例阑尾类癌肿瘤。观察到女孩明显过多（P = 0.02）。所有肿瘤均为偶然发现，2例患者接受了进一步手术。29个确诊部位中的22个（76%）位于阑尾尖端，40个肿瘤中的34个（85%）已侵犯阑尾黏膜下层以外。在整个研究期间，报告的每年每百万儿童1.14的发病率保持不变。未检测到肿瘤复发、转移或死亡。尽管偶尔需要进行右半结肠切除术，但单独阑尾切除术通常被确认为可治愈。建议在常规阑尾切除术中小心操作，以避免可能的肿瘤损伤，对儿科年龄组的所有阑尾进行一致的组织学检查也是如此。强调了长期随访的重要性。
