Fujimoto K, Machidori H, Iwakiri R, Yamamoto K, Fujisaki J, Sakata T, Tso P
Department of Internal Medicine, Saga Medical School, Japan.
Brain Res. 1993 Apr 16;608(2):233-7. doi: 10.1016/0006-8993(93)91463-3.
To characterize the anorectic effect of apolipoprotein A-IV (apo A-IV), we examined the effect of apo A-IV on the patterns of feeding, drinking and ambulation of rats fed ad libitum. A single dose of 200, 135 or 60 micrograms was infused intravenously through a chronically indwelling right atrial catheter just before the dark period. Apo A-IV suppressed food intake by decreasing meal size, but did not affect the interval between meals, the speed of eating, or the latency to eat the first meal after infusion. The anorectic effect of apo A-IV was dose-dependent and was effective for about 3 h after the infusion. The anorectic effect of apo A-IV is specific because inactivation of apo A-IV abolishes its anorectic effect. The anorectic effect of apo A-IV is not shared by apo A-I. Apo A-IV had no effect on drinking behavior or ambulatory activity. The results seem to indicate that apo A-IV specifically decreases the meal size, which supports our hypothesis that apo A-IV may act as a physiological signal for satiation after the ingestion of a lipid meal.
为了描述载脂蛋白A-IV（apo A-IV）的食欲抑制作用，我们研究了apo A-IV对自由进食大鼠的进食、饮水和活动模式的影响。在黑暗期开始前，通过长期留置的右心房导管静脉注射200、135或60微克的单一剂量。apo A-IV通过减小餐量来抑制食物摄入，但不影响餐间间隔、进食速度或注射后第一餐的进食潜伏期。apo A-IV的食欲抑制作用呈剂量依赖性，注射后约3小时有效。apo A-IV的食欲抑制作用具有特异性，因为apo A-IV的失活会消除其食欲抑制作用。apo A-I不具有apo A-IV的食欲抑制作用。apo A-IV对饮水行为或活动没有影响。结果似乎表明，apo A-IV特异性地减小餐量，这支持了我们的假设，即apo A-IV可能作为脂质餐后饱腹感的生理信号。
