某些胆碱能激动剂对基底前脑损伤大鼠新皮质慢波活动的影响。

Effects of some cholinergic agonists on neocortical slow wave activity in rats with basal forebrain lesions.

作者信息

Vanderwolf C H, Raithby A, Snider M, Cristi C, Tanner C

机构信息

Department of Psychology, University of Western Ontario, London, Canada.

出版信息

Brain Res Bull. 1993;31(5):515-21. doi: 10.1016/0361-9230(93)90118-u.

DOI:10.1016/0361-9230(93)90118-u

PMID:8495376

Abstract

Chronic rats, prepared with unilateral injections of kainic acid in the left basal forebrain, displayed prominent large amplitude slow wave activity in the neocortex ipsilateral to the injection. Oxotremorine and pilocarpine, given systemically following pretreatment with methyl scopolamine to block peripheral muscarinic effects, restored low voltage fast activity (LVFA) in a dose-related manner. Oxotremorine was more potent than pilocarpine. Arecoline was not consistently effective. Tetrahydroaminoacridine abolished abnormal 4-6 Hz rhythmical slow waves in the left neocortex but had little effect on large amplitude irregular slow waves. Direct-acting cholinergic agonists can restore near-normal neocortical activity after extensive cholinergic deafferentation of the neocortex.

摘要

通过在左侧基底前脑单侧注射海藻酸制备的慢性大鼠，在注射同侧的新皮层中表现出显著的大幅度慢波活动。在用甲基东莨菪碱预处理以阻断外周毒蕈碱效应后全身给予氧化震颤素和毛果芸香碱，以剂量相关的方式恢复了低电压快活动（LVFA）。氧化震颤素比毛果芸香碱更有效。槟榔碱并非始终有效。他克林消除了左侧新皮层中异常的4-6Hz节律性慢波，但对大幅度不规则慢波影响很小。直接作用的胆碱能激动剂可在新皮层广泛胆碱能去传入后恢复接近正常的新皮层活动。