Inhibition of peripheral fast synaptic inputs to celiac ganglion neurons by splanchnic preganglionic fibers in the cat.

Fast nicotinic transmission was studied in vitro in isolated cat celiac ganglion neurons using intracellular recording techniques. Fast synaptic activation was evoked by stimulation (0.1 Hz) of the anterior peripheral rami. A long-lasting inhibition of this response was triggered by repetitive splanchnic stimulation (30-50 Hz) for 10 s. Evidence is given that this inhibition occurs at presynaptic level. Our results indicate that central inputs modulate transmission of fast synaptic peripheral inputs to prevertebral ganglionic neurons. This would be another integrative mechanism in the prevertebral ganglia.