Olsen T S
Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark.
Cephalalgia. 1993 Apr;13(2):86-8. doi: 10.1046/j.1468-2982.1993.1302086.x.
The view that "spreading oligemia" reflects spreading depression in the human brain during the migraine aura is based on a defective analysis of CBF data where the most important methodological source of error (scattered radiation) has been ignored. When scattered radiation is taken into account it appears that CBF in the low flow area during the migraine aura is reduced to the ischemic level. There is no reason to believe that "spreading" of the low flow area occurs. Most likely the blood flow decreases in an area of fixed size. All available CBF evidence in fact lends support to "the vascular theory" of migraine pathogenesis.
“扩散性贫血”反映偏头痛先兆期间人脑存在扩散性抑制这一观点，是基于对脑血流量（CBF）数据的缺陷性分析，其中最重要的方法学误差来源（散射辐射）被忽略了。当考虑散射辐射时，偏头痛先兆期间低血流区域的CBF似乎降至缺血水平。没有理由相信低血流区域会发生“扩散”。最有可能的是，固定大小区域内的血流减少。实际上，所有现有的CBF证据都支持偏头痛发病机制的“血管理论”。
