Westerveld H T, de Graaf J C, van Breugel H H, Akkerman J W, Sixma J J, Erkelens D W, Banga J D
Department of Internal Medicine and Hematology, University Hospital Utrecht, The Netherlands.
Diabetes Care. 1993 May;16(5):683-8. doi: 10.2337/diacare.16.5.683.
To assess the effects of low-dose eicosapentaenoic acid-ethyl-ester on diabetes regulation, lipid metabolism, blood rheology, and platelet reactivity.
In a double-blind, randomized, placebo-controlled study, 24 NIDDM subjects received 1800 mg of EPA-E, 900 mg of EPA-E, or a placebo (1656 mg olive oil) daily for 8 wk.
The EPA:arachidonic acid plasma ratio increased over an 8-wk period, then declined after a 4-wk wash-out period in the fish-oil groups in a dose-dependent way. Platelet-activating factor-induced platelet aggregation decreased from 75 +/- 7% at wk 0 to 35 +/- 21% at wk 8 in the 900-mg group (P = 0.016) and from 72 +/- 11 to 40 +/- 30% in the 1800-mg group (P = 0.039), but did not change in the placebo group. No effects on ADP- or collagen-induced aggregation could be attributed to EPA-E. In the 1800-mg group low-density-lipoprotein cholesterol increased significantly, without concomitant rise in apolipoprotein B. Triglycerides, glycemic control, lipoprotein (a), blood and plasma viscosity, erythrocyte deformability, and platelet adhesion to and aggregate formation on extracellular endothelial cell matrix were not significantly influenced.
Purified EPA-E in doses of 900 and 1800 mg reduces Platelet-activating factor-induced platelet aggregation without negatively affecting glycemic control. Low-density-lipoprotein cholesterol was elevated in the 1800-mg group.
评估低剂量二十碳五烯酸乙酯对糖尿病调节、脂质代谢、血液流变学和血小板反应性的影响。
在一项双盲、随机、安慰剂对照研究中，24名非胰岛素依赖型糖尿病受试者每天接受1800毫克二十碳五烯酸乙酯、900毫克二十碳五烯酸乙酯或安慰剂（1656毫克橄榄油），持续8周。
在鱼油组中，二十碳五烯酸：花生四烯酸血浆比值在8周内升高，然后在4周洗脱期后呈剂量依赖性下降。在900毫克组中，血小板活化因子诱导的血小板聚集从第0周的75±7%降至第8周的35±21%（P = 0.016），在1800毫克组中从72±11%降至40±30%（P = 0.039），而安慰剂组无变化。二十碳五烯酸乙酯对二磷酸腺苷或胶原诱导的聚集没有影响。在1800毫克组中，低密度脂蛋白胆固醇显著升高，而载脂蛋白B没有相应升高。甘油三酯、血糖控制、脂蛋白(a)、血液和血浆粘度、红细胞变形性以及血小板对细胞外内皮细胞基质的粘附和聚集形成均未受到显著影响。
900毫克和1800毫克剂量的纯化二十碳五烯酸乙酯可降低血小板活化因子诱导的血小板聚集，且不会对血糖控制产生负面影响。1800毫克组的低密度脂蛋白胆固醇升高。
