Palma V, Guadagnino M, Brescia Morra V, Nolfe G
Division of Neurophysiopathology, San Gennaro Hospital, Naples, Italy.
Electromyogr Clin Neurophysiol. 1993 Apr-May;33(3):167-71.
The involvement of sensory pathways in patients suffering from amyotrophic lateral sclerosis (ALS) is well reported in histopathological studies. Several laboratories have also used evoked potentials to evidentiate subtle dysfunctions of sensory systems in such patients. However, conflicting results have been presented in studies using evoked potentials. In the present experiment we have evaluated multimodality evoked potentials in subjects with sure diagnosis of sporadic ALS, by means of the Bonferroni multiple comparisons procedure. Our principal findings are: a) no statistical difference between patients and controls in BAEP and VEP recordings; b) a reduction of N13 amplitude and a prolonged P22 latency in SEP recordings. Due to the sources of N13 and P22, these latter alterations, however, do not implicate the involvement of somatosensory pathway. In conclusion, the current investigation does not provide an electrophysiological support for the involvement of sensory systems in the sporadic ALS.
在组织病理学研究中，肌萎缩侧索硬化症（ALS）患者感觉通路受累情况已有充分报道。一些实验室也利用诱发电位来证实此类患者感觉系统的细微功能障碍。然而，使用诱发电位的研究得出了相互矛盾的结果。在本实验中，我们通过Bonferroni多重比较程序，对确诊为散发性ALS的受试者进行了多模态诱发电位评估。我们的主要发现如下：a）患者与对照组在脑干听觉诱发电位（BAEP）和视觉诱发电位（VEP）记录中无统计学差异；b）体感诱发电位（SEP）记录中N13波幅降低，P22潜伏期延长。然而，由于N13和P22的起源，后一种改变并不意味着体感通路受累。总之，目前的研究并未为散发性ALS中感觉系统受累提供电生理支持。
