Shoham Z, Jacobs H S, Insler V
Department of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel.
Fertil Steril. 1993 Jun;59(6):1153-61. doi: 10.1016/s0015-0282(16)55968-8.
To review studies that have examined the role of LH, its mechanism of action, and its detrimental effects when hypersecreted during the follicular phase.
Important published studies related to this topic were identified through a computerized bibliographic search.
PATIENTS, PARTICIPANTS: Review of the need for LH during the follicular phase is based on animal models and women with hypogonadotropic hypogonadism. The association of hypersecretion of LH during the follicular phase with low rates of fertilization and high rates of pregnancy loss is based on clinical studies conducted in patients treated by IVF and ET and by induction of ovulation. The possible mechanism by which the effects occur is based on in vitro studies.
The results of the studies cited in this review are consistent with the two-cell two-gonadotropin hypothesis implying that synergistic action of both FSH and LH is required for appropriate steroidogenesis. It also seems that, whatever the underlying mechanism, a raised serum LH concentration during the follicular phase confers a substantial risk of infertility and early pregnancy loss.
By reviewing the literature it appears that LH exhibits an important role in the development of the growing follicle and maturation of the oocyte. It also seems that hypersecretion of LH during the follicular phase implies adverse effects on the fertility process. To further test this hypothesis, we now need systemic assessment of the methods of therapy used for treating patients with polycystic ovary syndrome, in relation to LH secretion and outcome of pregnancy.
综述研究促黄体生成素（LH）的作用、作用机制及其在卵泡期分泌过多时的有害影响。
通过计算机化文献检索确定与该主题相关的重要已发表研究。
患者、参与者：基于动物模型和低促性腺激素性性腺功能减退的女性来综述卵泡期对LH的需求。卵泡期LH分泌过多与低受精率和高流产率之间的关联基于对接受体外受精-胚胎移植（IVF-ET）和诱导排卵治疗的患者进行的临床研究。效应发生的可能机制基于体外研究。
本综述引用的研究结果与双细胞双促性腺激素假说一致，这意味着适当的类固醇生成需要促卵泡生成素（FSH）和LH的协同作用。无论潜在机制如何，卵泡期血清LH浓度升高似乎都会带来不育和早期流产的重大风险。
通过回顾文献，LH似乎在生长卵泡的发育和卵母细胞的成熟中发挥重要作用。卵泡期LH分泌过多似乎也意味着对生育过程有不利影响。为了进一步验证这一假说，我们现在需要系统评估用于治疗多囊卵巢综合征患者的治疗方法与LH分泌和妊娠结局的关系。
