Kannegieter L S, Brandon J C, Espinoza F P, Vanson D T, Deutsch L S, Miller D P, Teplick S K
Department of Radiological Sciences, University of California, Irvine 92668.
Invest Radiol. 1993 May;28(5):420-6. doi: 10.1097/00004424-199305000-00007.
The authors evaluated a method of gallbladder sclerosis in the presence of cholelithiasis.
The study was performed in 20 pigs. The gallbladders of 16 pigs contained surgically placed human gallstones. Control groups included animals that had their gallbladders sclerosed in the absence of stones, as well as a surgical sham control. Sclerosis followed cystic duct ligation to prevent extravasation of the sclerosing agent (95% Ethanol with 2 mole% trifluoroacetic acid) into the biliary tree. After sclerosis, a pigtail catheter was placed in the gallbladder to drain any post-procedure fluid accumulations. Catheters were removed after all drainage had ceased. Animals were killed at either 8 weeks (n = 6) or 6 months (n = 14).
Stones were enveloped within the sclerosed and fibrotic gallbladder remnant in 13 of 15 test animals (87%).
Sclerosis of gallbladders with stones in situ was achievable. Total mucosal obliteration did not appear to be required to produce a dysfunctional gallbladder in the time frame of this study.
作者评估了在存在胆结石的情况下胆囊硬化的一种方法。
该研究在20头猪身上进行。16头猪的胆囊中通过手术植入了人类胆结石。对照组包括在无结石情况下胆囊硬化的动物，以及手术假对照。硬化过程在结扎胆囊管后进行，以防止硬化剂（含2摩尔%三氟乙酸的95%乙醇）渗入胆管树。硬化后，在胆囊内放置一根猪尾导管以引流术后任何液体积聚。所有引流停止后取出导管。动物在8周（n = 6）或6个月（n = 14）时处死。
15只试验动物中的13只（87%）结石被包裹在硬化和纤维化的胆囊残余物中。
原位硬化有结石的胆囊是可行的。在本研究的时间范围内，似乎不需要完全消除黏膜来使胆囊功能失调。
