Cullen M K, Lapierre L A, Kesari K V, Geliebter J
Howard Hughes Medical Institute, New York, New York 10021.
J Exp Med. 1993 Jun 1;177(6):1803-7. doi: 10.1084/jem.177.6.1803.
Structural diversity enables class Ia molecules to present a diverse repertoire of peptides to the T cell receptor. This diversity is thought to be generated by recombinations between class I genes. We have found that two class Ib Q2 alleles exhibit extremely high sequence diversity, even higher than class Ia alleles. Clustered nucleotide differences between Q2b and Q2k suggest that this sequence diversity was generated by microrecombinations between Q2 genes and other class I genes. The relatively high expression of Q2b in the thymus may be significant and perhaps suggests a novel role for a Q2b product in the education and selection of the T cell repertoire.
结构多样性使I类分子能够向T细胞受体呈递多种肽段。这种多样性被认为是由I类基因之间的重组产生的。我们发现，两个I类b型Q2等位基因表现出极高的序列多样性，甚至高于I类a型等位基因。Q2b和Q2k之间的聚类核苷酸差异表明，这种序列多样性是由Q2基因与其他I类基因之间的微重组产生的。Q2b在胸腺中的相对高表达可能具有重要意义，也许暗示了Q2b产物在T细胞库的教育和选择中的新作用。
