小鼠H-2Kk基因的完整核苷酸序列。三种H-2K基因座等位基因的比较。
Complete nucleotide sequence of the murine H-2Kk gene. Comparison of three H-2K locus alleles.
作者信息
Arnold B, Burgert H G, Archibald A L, Kvist S
出版信息
Nucleic Acids Res. 1984 Dec 21;12(24):9473-87. doi: 10.1093/nar/12.24.9473.
Abstract
We have determined the DNA sequence of the H-2Kk gene of the mouse major histocompatibility complex (MHC). Comparison on the nucleotide and protein level of three H-2K alleles (Kk, Kb and Kd) reveals a high degree of homology, in particular between the Kb and Kk alleles. Differences between the two latter antigens are almost exclusively confined to the alpha 1 and alpha 2 domains. At nine positions in the extracellular part of the molecules we have found allele-specific amino acids. Interestingly, 78% of these residues are either polar or carry hydroxyl-groups. This makes it likely that they are exposed on the surface of the molecules and might then be part of antigenic determinants. We have also identified potentially allele-specific nucleotide sequences of the K genes which might be used as specific DNA probes.
摘要
我们已经测定了小鼠主要组织相容性复合体（MHC）的H-2Kk基因的DNA序列。对三个H-2K等位基因（Kk、Kb和Kd）在核苷酸和蛋白质水平上的比较显示出高度的同源性，特别是在Kb和Kk等位基因之间。后两种抗原之间的差异几乎完全局限于α1和α2结构域。在分子细胞外部分的九个位置，我们发现了等位基因特异性氨基酸。有趣的是，这些残基中有78%要么是极性的，要么带有羟基。这使得它们很可能暴露在分子表面，进而可能成为抗原决定簇的一部分。我们还鉴定出了K基因潜在的等位基因特异性核苷酸序列，可将其用作特异性DNA探针。
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