Parham P, Lomen C E, Lawlor D A, Ways J P, Holmes N, Coppin H L, Salter R D, Wan A M, Ennis P D
Department of Cell Biology, Stanford University School of Medicine, CA 94305.
Proc Natl Acad Sci U S A. 1988 Jun;85(11):4005-9. doi: 10.1073/pnas.85.11.4005.
Diversity in 39 HLA-A, -B, and -C molecules is derived from 20 amino acid positions of high variability and 71 positions of low variability. Variation in the structurally homologous alpha 1 and alpha 2 domains is distinct and may correlate with partial segregation of peptide and T-cell receptor binding functions. Comparison of 15 HLA-A with 20 HLA-B molecules reveals considerable locus-specific character, due primarily to differences at polymorphic residues. The results indicate that genetic exchange between alleles of the same locus has been a more important mechanism in the generation of HLA-A, -B, and -C diversity than genetic exchange events between alleles of different loci.
39种HLA - A、- B和 - C分子的多样性源自20个高变异性氨基酸位置和71个低变异性位置。结构同源的α1和α2结构域的变异是不同的，并且可能与肽和T细胞受体结合功能的部分分离相关。15种HLA - A分子与20种HLA - B分子的比较显示出相当大的位点特异性特征，这主要是由于多态性残基的差异。结果表明，同一位点等位基因之间的基因交换在HLA - A、- B和 - C多样性的产生中比不同位点等位基因之间的基因交换事件更为重要。
