Oosthuizen W T, Erasmus J B, Boelema E, Grové J T
Rumevite Animal Care, Elarduspark, Republic of South Africa.
J S Afr Vet Assoc. 1993 Mar;64(1):28-30.
The efficacy of injectable and oral formulations of moxidectin, at a dosage of 0.2 mg kg -1 live mass was evaluated by the non-parametric method (NPM) against the most common internal parasites of sheep in 9 trials involving a total of 201 sheep. Both formulations obtained an A classification (more than 80% effective in more than 80% of the treated animals) against the third (L3) and fourth (L4) larval and adult stages of Haemonchus contortus, Teladorsagia circumcineta, Trichostrongylus colubriformis, Gaigeria pachyscelis, Chabertia ovina, Oesophagostomum columbianum and Dictyocaulus filaria, and L3 Nematodirus spathiger. The injectable formulation was similarly effective against L4 Strongyloides papillosus and the oral formulation against L4 N. spathiger and adult S. papillosus and N. spathiger. In contrast, a B classification (more than 60% effective in more than 60% of the treated animals) was obtained by the oral formulation against L4 of S. papillosus and by the injectable formulation against L4 and adult N. spathigher. Both formulations were ineffective against L3 S. papillosus, and the oral formulation also against the adults of this species.
采用非参数法（NPM），在9项试验中对总共201只绵羊，评估了剂量为0.2毫克/千克活体重的莫昔克丁注射剂和口服制剂对绵羊最常见体内寄生虫的疗效。两种制剂对捻转血矛线虫、环形泰勒虫、蛇形毛圆线虫、厚尾盖头线虫、绵羊夏伯特线虫、哥伦比亚食道口线虫、丝状网尾线虫的第三期（L3）和第四期（L4）幼虫以及成虫阶段，以及L3阶段的斯氏艾美耳球虫均获得了A级分类（在超过80%的治疗动物中有效性超过80%）。注射剂对L4阶段的乳头类圆线虫同样有效，口服制剂对L4阶段的斯氏艾美耳球虫以及成虫阶段的乳头类圆线虫和斯氏艾美耳球虫有效。相比之下，口服制剂对L4阶段的乳头类圆线虫获得了B级分类（在超过60%的治疗动物中有效性超过60%），注射剂对L4阶段和成虫阶段的斯氏艾美耳球虫获得了B级分类。两种制剂对L3阶段的乳头类圆线虫均无效，口服制剂对该物种的成虫也无效。
