Berger J
J S Afr Vet Assoc. 1980 Mar;51(1):51-8.
In a series of 11 trials, in which 281 lambs were artificially infected with 9 species of nematodes, larval anthelmintic tests were carried out to assess the activity of a dose of 5 mg/kg oxfendazole against all 3 parasitic stages of each species. An efficacy of over 99,4% was obtained against all stages of Haemonchus contortus, Ostertagia circumcincta, Trichostrongylus colubriformis, Nematodirus spathiger, Gaigeria pachyscelis, Chabertia ovina and Oesophagostomum columbianum with the exception of the third larval stage of O. Columbianum for which an efficacy of 93,5% was recorded. Against Dictyocaulus filaria efficacies against the fifth stages and adults, fourth larval and third larval stages were 99,8%, 92,0% and 37,5% respectively, and in two additional tests against the combined third and fourth larval stages, efficacies of 86,4% and 85,3% were recorded. Efficacy against Strongyloides papillosus was poor. In 2 supplementary experiments oxfendazole exhibited a 92,2--94,8% efficacy against adults of the Boshof benzimidazole-resistant strain of H. contortus, the highest activity so far recorded against the strain of any benzimidazole tested.
在一系列11项试验中，281只羔羊被人工感染了9种线虫，进行了幼虫驱虫试验，以评估5毫克/千克奥芬达唑剂量对每种线虫的所有3个寄生阶段的活性。对捻转血矛线虫、环形奥斯特线虫、蛇形毛圆线虫、斯氏细颈线虫、厚尾盖尾线虫、绵羊夏伯特线虫和哥伦比亚食道口线虫的所有阶段，除哥伦比亚食道口线虫第三幼虫阶段的疗效为93.5%外，其余均获得了超过99.4%的疗效。对丝状网尾线虫，第五阶段和成虫、第四幼虫阶段和第三幼虫阶段的疗效分别为99.8%、92.0%和37.5%，在另外两项针对第三和第四幼虫阶段联合的试验中，记录的疗效分别为86.4%和85.3%。对乳头类圆线虫的疗效较差。在2项补充实验中，奥芬达唑对博肖夫捻转血矛线虫苯并咪唑抗性菌株的成虫表现出92.2%-94.8%的疗效，这是迄今为止对任何测试的苯并咪唑菌株记录的最高活性。
