Webber M P, Hauser W A
Albert Einstein College of Medicine, Bronx, New York City.
Public Health Rep. 1993 May-Jun;108(3):279-84.
The ecologic relationship between the incidence of reactive serologic tests for syphilis among 2,229 newborns and diagnoses that included cocaine dependence among 17,219 hospitalized women ages 15-44 in New York City was investigated. Citywide, race-specific and zip code-specific annual rates were computed. The residential zip codes were grouped into quartiles by cumulative level of diagnoses that included cocaine dependence, and citywide and race-specific annual rates of congenital syphilis were computed in each quartile. From 1982 to 1988, the citywide rate of congenital syphilis for all races increased from 1.2 to 5.8 per 1,000 live births, while rates of cocaine dependence discharges increased from 23.3 to 423.3 per 100,000 women of all races during the same period. For African American infants, citywide rates of congenital syphilis increased from 1.8 to 10.6 per 1,000 live births. In quartile-specific analyses of African American women and newborns, rates of congenital syphilis increased from 1.9 to 14.6 in the highest cocaine-exposure quartile; from 2.1 to 12.4 in the third; from 1.5 to 7.6 in the second; and, from 1.6 to 2.8 in the lowest cocaine-exposure quartile. This study provides support for the hypothesis that cocaine dependence in women may be associated with congenital syphilis infection.
对纽约市17219名年龄在15至44岁住院女性中可卡因依赖诊断情况与2229名新生儿梅毒反应性血清学检测发病率之间的生态关系进行了调查。计算了全市、按种族和按邮政编码划分的年发病率。根据包括可卡因依赖在内的诊断累积水平，将居住邮政编码分为四分位数，并计算每个四分位数中全市和按种族划分的先天性梅毒年发病率。1982年至1988年，所有种族的全市先天性梅毒发病率从每1000例活产1.2例增至5.8例，而同期所有种族每10万名女性中可卡因依赖出院率从23.3例增至423.3例。非裔美国婴儿的全市先天性梅毒发病率从每1000例活产1.8例增至10.6例。在对非裔美国女性和新生儿的四分位数特定分析中，在可卡因暴露最高的四分位数中，先天性梅毒发病率从1.9例增至14.6例；在第三四分位数中从2.1例增至12.4例；在第二四分位数中从1.5例增至7.6例；在可卡因暴露最低的四分位数中从1.6例增至2.8例。本研究为女性可卡因依赖可能与先天性梅毒感染相关这一假设提供了支持。
