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中国山东通过密切接触者症状筛查和痰检评估活动性肺结核病例发现。

Evaluation of active tuberculosis case finding through symptom screening and sputum microscopy of close contacts in Shandong, China.

机构信息

Shandong Provincial Chest Hospital, Jinan, Shandong Province, China.

出版信息

Trop Med Int Health. 2011 Dec;16(12):1511-7. doi: 10.1111/j.1365-3156.2011.02869.x. Epub 2011 Aug 18.

Abstract

OBJECTIVES

To evaluate the effect of active case finding through symptom screening and sputum microscopy of close contacts in a Fidelis (Fund for Innovative DOTS Expansion through Local Initiatives to Stop TB) project.

METHODS

Secondary data from all 35 counties were collected during implementation and used. They comprised new cases identified, number of close contacts screened and their relationships. Fifty-four in-depth interviews were conducted with staff from key stakeholders.

RESULTS

A total of 13 310 symptomatic contacts of 5255 index cases were screened, and 90 new smear-positive cases were detected with a yield rate of 0.7%. The yield rate of close contacts was positively associated with smear grades of the index cases (P<0.01). Close contacts of cases, such as classmates and workmates, who lived in a closed contained setting, had a higher yield rate than family members (P<0.001). Gaps in project implementation such as training, incentives and sputum collection were identified through in-depth interviews.

CONCLUSIONS

The yield rate of close-contact screening of 0.7% was similar to other findings in China. There was a higher yield from screening of close contacts in congregated settings like schools and workshops. Future active case finding projects should provide clear operational guidelines and adequate training.

摘要

目的

评估通过症状筛查和密切接触者痰检对菲得利斯(通过地方倡议促进创新的直接督导下的短程化疗扩展以终止结核基金)项目中的密切接触者开展主动病例发现的效果。

方法

在实施过程中收集了来自所有 35 个县的二次数据,并加以利用。这些数据包括发现的新病例数、接受筛查的密切接触者人数及其关系。对来自主要利益攸关方的工作人员进行了 54 次深入访谈。

结果

共对 5255 例确诊病例的 13310 例有症状接触者进行了筛查,检出 90 例新的涂片阳性病例,检出率为 0.7%。密切接触者的检出率与确诊病例的涂片等级呈正相关(P<0.01)。与家庭成员相比,生活在封闭环境中的确诊病例的同学和同事等密切接触者的检出率更高(P<0.001)。通过深入访谈发现,项目实施中存在培训、激励措施和痰标本采集等方面的差距。

结论

密切接触者筛查的检出率为 0.7%,与中国的其他发现相似。对学校和车间等聚集场所的密切接触者进行筛查的检出率更高。未来的主动病例发现项目应提供明确的操作指南和充分的培训。

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