Lim E C, Chia D, Gjertson D W, Koka P, Terasaki P I
University of the Philippines College of Medicine, Immunology Section.
Transplantation. 1993 May;55(5):996-9. doi: 10.1097/00007890-199305000-00008.
The pretransplant sera of 27 IgA nephropathy (N) kidney transplant patients were investigated for antibodies to the HLA molecule, together with 104 sera from non-IgA N patients and 60 controls. IgA antibodies to HLA were found in 61% of IgA N patients and 2% of non-IgA N patients. IgA N patients with IgA antibodies to HLA had a 100% 2-year cadaver donor graft survival rate compared with 70% in those without IgA antibodies. Patients with IgG antibodies to HLA without accompanying IgA antibodies had the worst graft survival rates. We propose that IgA anti-HLA contributes to the high kidney graft survival in IgA N patients by blocking IgG antibodies or inhibiting cellular immune response.
对27例IgA肾病（N）肾移植患者的移植前血清进行了HLA分子抗体检测，同时检测了104例非IgA肾病患者的血清和60例对照者的血清。在61%的IgA肾病患者和2%的非IgA肾病患者中发现了HLA的IgA抗体。有HLA IgA抗体的IgA肾病患者尸体供肾移植2年存活率为100%，而无IgA抗体者为70%。有HLA IgG抗体而无伴随IgA抗体的患者移植存活率最差。我们提出，IgA抗HLA通过阻断IgG抗体或抑制细胞免疫反应，有助于提高IgA肾病患者的肾移植存活率。
