Kozlov Iu A, Shevtsova N M, Pleshko R I, Kurlov O V, Baĭkov A N, Novitskiĭ V V
Vopr Med Khim. 1993 Jan-Feb;39(1):56-8.
A rate of incorporation of 3H-thymidine, 3H-uridine and 14C-glycine into the nucleoproteins of bone marrow, spleen, thymus and ileocecal lymph nodes was studied in BALB/c mice with hypothyrosis developed after administration of 1% KClO4 within a month. Distinct hypoplasia of bone marrow and spleen was found in the experimental animals; the synthesis of nucleoproteins was most impaired in bone marrow. The dependence of hemopoietic tissues on thyroid hormones was decreased as follows: bone marrow > spleen > thymus > lymph node. After subcutaneous administration of triiodothyronine (T3) in a dose of 50 mg/kg daily within 3 days of synthesis of nucleoproteins was considerably stimulated and the amount of cells was increased in bone marrow and spleen. Less distinct stimulating effect of T3 was observed in the thymus and lymph nodes of these animals.
研究了在一个月内给予1%高氯酸钾后发生甲状腺功能减退的BALB/c小鼠中，3H-胸腺嘧啶核苷、3H-尿苷和14C-甘氨酸掺入骨髓、脾脏、胸腺和回盲部淋巴结核蛋白中的速率。在实验动物中发现骨髓和脾脏明显发育不全；骨髓中核蛋白的合成受损最为严重。造血组织对甲状腺激素的依赖性降低顺序如下：骨髓＞脾脏＞胸腺＞淋巴结。在核蛋白合成的3天内，每天皮下注射剂量为50mg/kg的三碘甲状腺原氨酸（T3）后，骨髓和脾脏中核蛋白的合成受到显著刺激，细胞数量增加。在这些动物的胸腺和淋巴结中观察到T3的刺激作用不太明显。
