Mutter G L, Pomponio R J, Berkowitz R S, Genest D R
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
Am J Obstet Gynecol. 1993 May;168(5):1547-51. doi: 10.1016/s0002-9378(11)90796-0.
Complete hydatidiform moles have a substantial risk for subsequent development of persistent or metastatic gestational trophoblastic tumor. We evaluated the hypothesis that presence of a Y chromosome in a complete hydatidiform mole confers an increased risk for developing metastatic gestational trophoblastic tumor.
The polymerase chain reaction was applied to archival paraffin-embedded molar-tissue to identify Y chromosome-positive dispermic moles in patients who did or did not develop metastatic disease. To reduce the chances of analytic error, consensus polymerase chain reaction primers directed at homologous but different genes present on both X and Y chromosomes were used.
Y-chromosome sequences were identified in 7.7% (1/13) of the metastatic group and 9.1% (2/22) of the nonmetastatic group, a statistically insignificant difference.
We are unable to confirm any increased risk for metastasis in Y chromosome-positive compared with Y chromosome-negative complete hydatidiform mole.
完全性葡萄胎有很大风险随后发展为持续性或转移性妊娠滋养细胞肿瘤。我们评估了这样一个假说，即完全性葡萄胎中存在Y染色体使发生转移性妊娠滋养细胞肿瘤的风险增加。
应用聚合酶链反应检测存档的石蜡包埋的葡萄胎组织，以识别发生或未发生转移疾病患者中的Y染色体阳性双精子性葡萄胎。为降低分析误差的几率，使用了针对X和Y染色体上同源但不同基因的一致性聚合酶链反应引物。
在转移组的7.7%（1/13）和非转移组的9.1%（2/22）中鉴定出Y染色体序列，差异无统计学意义。
我们无法证实与Y染色体阴性的完全性葡萄胎相比，Y染色体阳性的完全性葡萄胎发生转移的风险有任何增加。
