Schnell C R, Wood J M
Cardiovascular Research Department, Ciba-Geigy, Basel, Switzerland.
Am J Physiol. 1993 May;264(5 Pt 2):H1509-16. doi: 10.1152/ajpheart.1993.264.5.H1509.
A system is described for the continuous measurement of blood pressure, heart rate, and motor activity by telemetry in conscious marmosets freely moving in their home cages. Consistent diurnal variations in these parameters were observed under standard conditions, although these parameters were sensitive to changes in the environment. Blood pressure values were similar to those measured by nontelemetric methods in conscious, restrained marmosets. However, heart rate was lower, indicating that telemetry is less stressful. The suitability of this system for assessing the effects of blood pressure-lowering drugs was evaluated. An acute or a prolonged treatment with a converting enzyme inhibitor of marmosets maintained on a low-sodium diet induced a fall in blood pressure as previously observed using nontelemetric methods. With telemetry, however, more accurate information on the duration of response and the effects of the treatment on the diurnal rhythms was obtained. These observations demonstrate the advantages of telemetry for evaluating the hemodynamic effects of drug treatments under physiological conditions.
描述了一种通过遥测技术对在其家笼中自由活动的清醒狨猴连续测量血压、心率和运动活动的系统。在标准条件下观察到这些参数存在一致的昼夜变化，尽管这些参数对环境变化敏感。血压值与通过非遥测方法在清醒、受限的狨猴中测量的值相似。然而，心率较低，表明遥测技术造成的压力较小。评估了该系统用于评估降压药物效果的适用性。如先前使用非遥测方法所观察到的，对维持低钠饮食的狨猴进行急性或长期的转换酶抑制剂治疗会导致血压下降。然而，通过遥测技术，可以获得关于反应持续时间以及治疗对昼夜节律影响的更准确信息。这些观察结果证明了遥测技术在评估生理条件下药物治疗的血流动力学效应方面的优势。
