Sato K, Chatani F, Sato S
Department I, Takeda Chemical Industries, Ltd., Osaka, Japan.
J Auton Nerv Syst. 1995 Sep 5;54(3):235-46. doi: 10.1016/0165-1838(95)00016-q.
Blood pressure (BP) and heart rate (HR) were measured by telemetry in conscious unrestrained rabbits to clarify the profile of their variabilities. The variabilities were assessed for two periods, 24 h (circadian rhythm) and 1 h (short-term variability), and compared with those in rats. BP and HR in rabbits were lower than those in rats but the circadian rhythms in rabbits showed nocturnal patterns as is the case in rats. In contrast, short-term variabilities in BP in rabbits were considerably larger than those in rats. The short-term variability in BP in rabbits was suppressed by alpha-adrenergic blocking without changes in basal values but not by beta-adrenergic blocking or angiotensin converting enzyme inhibition. These results demonstrate the need to take the unique characteristics of short-term variability in BP in rabbit into consideration when the circadian rhythm is focused on and that the short-term variability in BP in rabbits is caused mainly by activation of alpha-adrenergic receptors.
