Page W F, Kurtzke J F, Murphy F M, Norman J E
Medical Follow-up Agency, Institute of Medicine/National Academy of Sciences, Veterans Affairs Medical Center, Washington, DC.
Ann Neurol. 1993 Jun;33(6):632-9. doi: 10.1002/ana.410330612.
Self-reported ancestry data for the U.S. population from the 1980 decennial census and multiple sclerosis (MS) risk data derived from a large series of World War II white male veterans with MS and matched controls were aggregated on a state level and analyzed to determine the relationship between ancestry and MS risk. A significant portion of the state-by-state variation in MS risk is explainable statistically by differences in ancestry among state populations, even when geographic latitude is included in analyses. In the main, Swedish and other Scandinavian ancestry is most consistently associated with places with increased MS risk. In some analyses, Italian, French, and (to a lesser extent) Scottish ancestries are also associated with increased risk, whereas English and Dutch ancestries are each associated with decreased risk, but most of these non-Scandinavian correlations may reflect predominantly geography per se. These findings provide evidence that ancestry of the resident population, a confounded measure of genetic susceptibility and cultural environment, is part of the complicated picture of MS as a disease of place.
我们将1980年美国十年一度人口普查中的自我报告血统数据，以及来自一大批患有多发性硬化症（MS）的二战白人男性退伍军人及其匹配对照的MS风险数据，按州进行汇总并分析，以确定血统与MS风险之间的关系。即使在分析中纳入地理纬度，MS风险在各州之间的显著差异在统计学上也可由各州人口血统差异来解释。总体而言，瑞典和其他斯堪的纳维亚血统与MS风险增加的地区最密切相关。在一些分析中，意大利、法国和（程度较轻的）苏格兰血统也与风险增加有关，而英格兰和荷兰血统则与风险降低有关，但这些非斯堪的纳维亚血统的相关性大多可能主要反映了地理因素本身。这些发现证明，作为遗传易感性和文化环境的混杂指标，常住人口的血统是MS作为一种与地域相关疾病的复杂情况的一部分。
