Balázs M
Department of Pathology, János Hospital, Budapest, Hungary.
Zentralbl Pathol. 1993 Mar;139(1):11-6.
Eight cases of upper gastro-intestinal bleeding associated with liver cirrhosis are reported in this paper. Morphological studies revealed gastroduodenal ulceration with severe vascular changes in the mucosa and submucosa layer. Capillary dilatation was seen in the superficial region of the mucosa. Thick-walled and tortuous vessels similar to angiodysplasia were noted in the submucosa. The latter vessels were surrounded by scar-like connective tissue considerably thickening the gastric submucous layer. It is assumed that scar-like thickening of the submucous layer surrounding the tele-angiectatic vessels causes microcirculatory disorders thus giving rise to bleeding ulcers.
本文报告了8例与肝硬化相关的上消化道出血病例。形态学研究显示胃十二指肠溃疡，黏膜及黏膜下层有严重的血管改变。在黏膜表层可见毛细血管扩张。在黏膜下层可见类似于血管发育异常的厚壁迂曲血管。后者被瘢痕样结缔组织包围，使胃黏膜下层明显增厚。据推测，远侧毛细血管扩张血管周围黏膜下层的瘢痕样增厚导致微循环障碍，从而引起出血性溃疡。
