Fernández-Britto J E, de la Fuente F, Meitín J J, Marrero M, Yero M, Guski H
Havana Atherosclerosis Research and Reference Center, Hospital Dr. C. J. Finlay, Cuba.
Zentralbl Pathol. 1993 Mar;139(1):61-5.
An atherometric system (AS) was used to study coronary atherosclerotic lesions of a sample of 73 autopsy subjects. The content of nine chemical elements in the hair (K, Ca, Zn, Br, Sr, Pb, S, Cl, Cu) and the rates Zn/Cu and Ca/K were determined by energy dispersive X-ray fluorescence (EDXRF) analysis. Some canonical correlation analyses (CCA) were made of different combinations of chemical elements contents and of the following descriptive arterial variables of As: fatty streaks, fibrous plaques, severe (complicated plus calcified), plaques, and total atherosclerosis and the three weighted indices of AS, i.e. obstruction, stenosis and benignity. The arterial variables were obtained from the three major epicardial branches of the coronary arteries. Similar CCA analyses were performed to correlate chemical elements of the hair with some heart variables of AS, such as heart weight and estimated total volume of myocardium damaged by fibrosis and/or necrosis. The most remarkable results were as follows: Combinations of Pb, Ca/K, Zn/Cu and Fe, Ca/K, Zn/Cu were always strongly correlated with fatty streaks, fibrous plaques and severe plaques of the three coronary artery branches and the total coronary artery system, with the only exception of the left circumflex coronary artery when Fe was included. Similar results were recorded from obstruction, stenosis and benignity indices of AS. These two combinations of chemical elements were also correlated with the heart variables of AS. When the group of elements was integrated by Br, Ca/K, Zn/Cu, there were significant results with the heart variables, but not with the arterial variables of the AS.
使用一种动脉粥样硬化测量系统（AS）对73例尸检对象样本的冠状动脉粥样硬化病变进行研究。通过能量色散X射线荧光（EDXRF）分析测定头发中九种化学元素（钾、钙、锌、溴、锶、铅、硫、氯、铜）的含量以及锌/铜和钙/钾的比率。对化学元素含量的不同组合与AS的以下描述性动脉变量进行了一些典型相关分析（CCA）：脂肪条纹、纤维斑块、重度（复杂加钙化）斑块、斑块以及总动脉粥样硬化，以及AS的三个加权指数，即阻塞、狭窄和良性。动脉变量取自冠状动脉的三个主要心外膜分支。进行了类似的CCA分析，以将头发中的化学元素与AS的一些心脏变量相关联，例如心脏重量以及因纤维化和/或坏死而受损的心肌估计总体积。最显著的结果如下：铅、钙/钾、锌/铜的组合以及铁、钙/钾、锌/铜的组合始终与三个冠状动脉分支和整个冠状动脉系统的脂肪条纹、纤维斑块和重度斑块密切相关，唯一的例外是当包含铁时左回旋支冠状动脉。从AS的阻塞、狭窄和良性指数也记录到了类似结果。这两种化学元素组合也与AS的心脏变量相关。当元素组由溴、钙/钾、锌/铜组成时，与心脏变量有显著结果，但与AS的动脉变量无显著结果。
