选择性5-羟色胺再摄取抑制剂（SSRI）对自杀意念的影响：459例抑郁症患者的回顾性研究
Reduction in suicidal ideation with SSRIs: a review of 459 depressed patients.
作者信息
Filteau M J, Lapierre Y D, Bakish D, Blanchard A
机构信息
Department of Psychiatry, Hôpital de l'Enfant-Jésus, Quebec.
出版信息
J Psychiatry Neurosci. 1993 May;18(3):114-9.
Abstract
This paper is a review of 459 outpatients treated in double-blind clinical drug trials using similar protocols which compared the clinical responses to specific serotonin reuptake inhibitors, norepinephrine reuptake inhibitors, mixed norepinephrine serotonin reuptake inhibitors, serotonin-2 antagonists and placebo. Although improvements in the total score on the Hamilton Rating Scale for Depression did not differ significantly among the groups, there were differences in the profile of response based on analysis of the items of the scale. The most striking difference was the significantly more rapid and effective improvement in depressed mood and the lessening of suicidal ideation among the patients treated with specific serotonin reuptake inhibitors.
摘要
本文是对459名门诊患者的回顾，这些患者参与了双盲临床药物试验，试验采用了相似的方案，比较了特定5-羟色胺再摄取抑制剂、去甲肾上腺素再摄取抑制剂、去甲肾上腺素-5-羟色胺混合再摄取抑制剂、5-羟色胺-2拮抗剂及安慰剂的临床反应。尽管汉密尔顿抑郁评定量表总分的改善在各治疗组间无显著差异，但根据量表项目分析，反应情况有所不同。最显著的差异是，使用特定5-羟色胺再摄取抑制剂治疗的患者，其抑郁情绪改善更快、更有效，自杀观念减轻。
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