选择性5-羟色胺再摄取抑制剂（SSRI）对自杀意念的影响：459例抑郁症患者的回顾性研究
Reduction in suicidal ideation with SSRIs: a review of 459 depressed patients.
作者信息
Filteau M J, Lapierre Y D, Bakish D, Blanchard A
机构信息
Department of Psychiatry, Hôpital de l'Enfant-Jésus, Quebec.
出版信息
J Psychiatry Neurosci. 1993 May;18(3):114-9.
Abstract
This paper is a review of 459 outpatients treated in double-blind clinical drug trials using similar protocols which compared the clinical responses to specific serotonin reuptake inhibitors, norepinephrine reuptake inhibitors, mixed norepinephrine serotonin reuptake inhibitors, serotonin-2 antagonists and placebo. Although improvements in the total score on the Hamilton Rating Scale for Depression did not differ significantly among the groups, there were differences in the profile of response based on analysis of the items of the scale. The most striking difference was the significantly more rapid and effective improvement in depressed mood and the lessening of suicidal ideation among the patients treated with specific serotonin reuptake inhibitors.
摘要
本文是对459名门诊患者的回顾，这些患者参与了双盲临床药物试验，试验采用了相似的方案，比较了特定5-羟色胺再摄取抑制剂、去甲肾上腺素再摄取抑制剂、去甲肾上腺素-5-羟色胺混合再摄取抑制剂、5-羟色胺-2拮抗剂及安慰剂的临床反应。尽管汉密尔顿抑郁评定量表总分的改善在各治疗组间无显著差异，但根据量表项目分析，反应情况有所不同。最显著的差异是，使用特定5-羟色胺再摄取抑制剂治疗的患者，其抑郁情绪改善更快、更有效，自杀观念减轻。
相似文献
1
Reduction in suicidal ideation with SSRIs: a review of 459 depressed patients.选择性5-羟色胺再摄取抑制剂（SSRI）对自杀意念的影响：459例抑郁症患者的回顾性研究
J Psychiatry Neurosci. 1993 May;18(3):114-9.
2
Suicidal risk during controlled clinical investigations of fluvoxamine.氟伏沙明对照临床研究期间的自杀风险。
J Clin Psychiatry. 1996 Sep;57(9):415-21.
3
Selective serotonin reuptake inhibitors (SSRIs) for depressive disorders in children and adolescents.用于儿童和青少年抑郁症的选择性5-羟色胺再摄取抑制剂（SSRI）
Cochrane Database Syst Rev. 2007 Jul 18(3):CD004851. doi: 10.1002/14651858.CD004851.pub2.
4
SSRIs in anxious-agitated depression: a post-hoc analysis of 279 patients.选择性5-羟色胺再摄取抑制剂治疗焦虑激越性抑郁症：279例患者的事后分析
Int Clin Psychopharmacol. 1995 Mar;10(1):51-4. doi: 10.1097/00004850-199503000-00007.
5
Depression-free days as a summary measure of the temporal pattern of response and remission in the treatment of major depression: a comparison of venlafaxine, selective serotonin reuptake inhibitors, and placebo.无抑郁天数作为重度抑郁症治疗中反应和缓解时间模式的汇总指标：文拉法辛、选择性5-羟色胺再摄取抑制剂与安慰剂的比较
J Clin Psychiatry. 2003 Mar;64(3):321-30. doi: 10.4088/jcp.v64n0315.
6
Coadministration of modafinil and a selective serotonin reuptake inhibitor from the initiation of treatment of major depressive disorder with fatigue and sleepiness: a double-blind, placebo-controlled study.从伴有疲劳和嗜睡的重度抑郁症治疗开始就合用莫达非尼和选择性5-羟色胺再摄取抑制剂：一项双盲、安慰剂对照研究。
J Clin Psychopharmacol. 2007 Dec;27(6):614-9. doi: 10.1097/jcp.0b013e31815abefb.
7
Decreased suicidal ideation in depressed patients with or without comorbid posttraumatic stress disorder treated with selective serotonin reuptake inhibitors: an open study.伴有或不伴有共病创伤后应激障碍的抑郁患者接受选择性 5-羟色胺再摄取抑制剂治疗后自杀意念减少：一项开放研究。
Psychiatry Res. 2012 Apr 30;196(2-3):261-6. doi: 10.1016/j.psychres.2011.11.010. Epub 2012 Mar 6.
8
Two items on the Hamilton Depression rating scale are effective predictors of remission: comparison of selective serotonin reuptake inhibitors with the combined serotonin/norepinephrine reuptake inhibitor, venlafaxine.汉密尔顿抑郁量表中的两项内容是缓解的有效预测指标：选择性5-羟色胺再摄取抑制剂与5-羟色胺/去甲肾上腺素再摄取抑制剂文拉法辛的比较。
Int Clin Psychopharmacol. 2002 Nov;17(6):273-80. doi: 10.1097/00004850-200211000-00002.
9
Platelet serotonin reuptake inhibition and response to SSRIs in depressed adolescents.血小板5-羟色胺再摄取抑制与抑郁青少年对选择性5-羟色胺再摄取抑制剂的反应
Am J Psychiatry. 2005 Apr;162(4):802-4. doi: 10.1176/appi.ajp.162.4.802.
10
Comparative efficacy between venlafaxine and SSRIs: a pooled analysis of patients with depression.文拉法辛与选择性5-羟色胺再摄取抑制剂（SSRI）的疗效比较：抑郁症患者的汇总分析
Biol Psychiatry. 2002 Dec 15;52(12):1166-74. doi: 10.1016/s0006-3223(02)01425-7.
引用本文的文献
1
Recommendations for Addressing Suicidal Ideation Precipitated by Levetiracetam in the Treatment of Seizure Disorder: A Case Report and Review of the Literature.左乙拉西坦治疗癫痫障碍引发自杀观念的处理建议：一例病例报告及文献综述
Cureus. 2025 Jul 14;17(7):e87919. doi: 10.7759/cureus.87919. eCollection 2025 Jul.
2
Antidepressants and Suicide Risk: A Comprehensive Overview.抗抑郁药与自杀风险：全面概述
Pharmaceuticals (Basel). 2010 Aug 30;3(9):2861-2883. doi: 10.3390/ph3092861.
3
Suicidality with selective serotonin reuptake inhibitors: Valid claim?选择性5-羟色胺再摄取抑制剂与自杀行为：合理的说法？
J Psychiatry Neurosci. 2003 Sep;28(5):340-7.
4
Management of resistant depression.难治性抑郁症的管理
Can Fam Physician. 1996 Oct;42:1973-80.
本文引用的文献
1
Biochemical markers in suicidal patients. Investigations with cerebrospinal fluid amine metabolites and neuroendocrine tests.自杀患者的生化标志物。脑脊液胺代谢产物及神经内分泌检测研究。
J Affect Disord. 1984 Jun;6(3-4):341-50. doi: 10.1016/s0165-0327(84)80012-9.
2
CSF 5-hydroxyindoleacetic acid levels in suicidal schizophrenic patients.自杀性精神分裂症患者脑脊液中5-羟吲哚乙酸水平
Am J Psychiatry. 1984 Apr;141(4):566-9. doi: 10.1176/ajp.141.4.566.
3
Development of a rating scale for primary depressive illness.原发性抑郁症评定量表的编制。
Br J Soc Clin Psychol. 1967 Dec;6(4):278-96. doi: 10.1111/j.2044-8260.1967.tb00530.x.
4
Paradoxical worsening of depressive symptomatology caused by antidepressants.抗抑郁药引起的抑郁症状反常恶化。
J Clin Psychopharmacol. 1988 Oct;8(5):347-9.
5
Why do some antidepressants promote suicide?为什么有些抗抑郁药会促发自杀行为？
Psychopharmacology (Berl). 1986;90(3):422. doi: 10.1007/BF00179204.
6
Denosologization of biological psychiatry or the specificity of 5-HT disturbances in psychiatric disorders.生物精神病学的去本体化或精神疾病中5-羟色胺紊乱的特异性。
J Affect Disord. 1987 Jul-Aug;13(1):1-8. doi: 10.1016/0165-0327(87)90067-x.
7
The serotonin hypothesis of (auto)aggression. Critical appraisal of the evidence.（自身）攻击行为的血清素假说。证据的批判性评估。
Ann N Y Acad Sci. 1986;487:150-67. doi: 10.1111/j.1749-6632.1986.tb27895.x.
8
Additional cases of suicidal ideation associated with fluoxetine.与氟西汀相关的自杀意念的其他病例。
Am J Psychiatry. 1990 Nov;147(11):1570-1. doi: 10.1176/ajp.147.11.aj147111570.
9
5-HT reuptake inhibitors, tricyclic antidepressants and suicidal behaviour.
Int Clin Psychopharmacol. 1991 Dec;6 Suppl 3:49-55; discussion 55-6. doi: 10.1097/00004850-199112003-00005.
10
Fluoxetine and suicide: a meta-analysis of controlled trials of treatment for depression.氟西汀与自杀：抑郁症治疗对照试验的荟萃分析
BMJ. 1991 Sep 21;303(6804):685-92. doi: 10.1136/bmj.303.6804.685.
Zotero 插件