Minciacchi D, Granato A, Santarelli M, Sbriccoli A
Laboratory of Experimental Neurology, Catholic University, Rome, Italy.
Neuroreport. 1993 Apr;4(4):415-8. doi: 10.1097/00001756-199304000-00019.
The present study aimed to investigate the organization of thalamo-cortical connections in adult rats exposed to ethanol during the last week of foetal life. Animals underwent thalamic injections of lectin-conjugated HRP. Results demonstrate that the thalamic-recipient zone of sensorimotor cortex is significantly thinner in ethanol-exposed than in control cases. Animals exposed to ethanol also display aberrant thalamo-cortical terminations in layer 5a. Neurones of origin of cortico-thalamic projections are normally located in layers 5 and 6; they appear quantitatively comparable in control and ethanol-exposed cases. Developmental alterations underlying the establishment of anomalous thalamo-cortical relationships are discussed.
本研究旨在调查在胎儿期最后一周接触乙醇的成年大鼠丘脑 - 皮质连接的组织情况。对动物进行丘脑注射凝集素结合的辣根过氧化物酶（HRP）。结果表明，与对照相比，暴露于乙醇的动物体感运动皮层的丘脑接受区明显更薄。暴露于乙醇的动物在5a层也显示出异常的丘脑 - 皮质终末。皮质 - 丘脑投射的起源神经元通常位于5层和6层；在对照和暴露于乙醇的动物中，它们在数量上相当。本文讨论了异常丘脑 - 皮质关系建立的发育改变。
