Santarelli M, Granato A, Sbriccoli A, Gobbi G, Janiri L, Minciacchi D
Department of Neurological and Psychiatric Sciences, University of Florence, Italy.
Brain Res. 1995 Nov 6;698(1-2):241-7. doi: 10.1016/0006-8993(95)00997-5.
We previously demonstrated that adult rats prenatally exposed to ethanol display permanent damages of thalamo-cortical connections [18,19,33]. Here the effect of simultaneous administration of ethanol and acetyl-L-carnitine has been investigated. Adult animals underwent cortical or thalamic injections of horseradish peroxidase and both anterograde and retrograde thalamic and cortical labeling have been analyzed. Ethanol-induced changes of thalamo-cortical circuits are prevented by concurrent administration of acetyl-L-carnitine. Possible mechanisms underlying this effect are discussed.
我们之前证明，产前暴露于乙醇的成年大鼠表现出丘脑-皮质连接的永久性损伤[18,19,33]。在此，我们研究了乙醇与乙酰-L-肉碱同时给药的效果。成年动物接受了皮质或丘脑辣根过氧化物酶注射，并对顺行和逆行的丘脑及皮质标记进行了分析。同时给予乙酰-L-肉碱可预防乙醇诱导的丘脑-皮质回路变化。讨论了这种效应潜在的可能机制。
