Toumba K J, Curzon M E
Department of Paediatric Dentistry, Leeds Dental Institute, UK.
Caries Res. 1993;27 Suppl 1:43-6. doi: 10.1159/000261601.
The latest evidence supports the concept of frequent applications of relatively low concentrations of fluoride for the elimination of caries, even in situations of high caries challenge. Dental materials exhibit a 'burst effect', and the fluoride release is short-lived. Intra-oral devices in the form of copolymer membranes or glass devices cause an elevation of salivary F levels for up to 2 years in animals and humans and have led to increased F uptake in enamel. Caries reduction has been achieved in rats using the copolymer device, and, at present, human caries trials using the copolymer and glass devices are under way in the USA and Leeds, respectively. These intra-oral devices hold great promise to target financial resources for prevention in groups of the population with high caries levels, in particular low socio-economic groups including ethnic minorities and the handicapped.
最新证据支持即使在龋齿高发的情况下，频繁应用相对低浓度氟化物以消除龋齿的理念。牙科材料呈现出“突发效应”，且氟化物释放是短暂的。共聚物膜或玻璃装置形式的口腔内装置可使动物和人类唾液氟水平升高长达2年，并导致牙釉质中氟摄取增加。使用共聚物装置在大鼠中已实现龋齿减少，目前，美国和利兹分别正在进行使用共聚物和玻璃装置的人体龋齿试验。这些口腔内装置极有希望将预防的财政资源用于龋齿高发人群，特别是包括少数民族和残疾人在内的低社会经济群体。
