Ofri R, Dawson W W, Foli K, Gelatt K N
Department of Ophthalmology, College of Medicine, JHMHC, University of Florida, Gainesville 32610.
Exp Eye Res. 1993 Apr;56(4):481-8. doi: 10.1006/exer.1993.1061.
Electrophysiological responses of the retina to a series of grating stimuli (6-768 min of arc/phase) were recorded in seven sessions using normal Beagles and in 21 sessions using Beagles afflicted with inherited glaucoma. A 15 degrees and a 30 degrees field, centered around the animal's area centralis, were used to stimulate the central retina. Two recording series were completed on each animal, with both stimulus sizes presented in each recording session. The first recording took place 30 min, and the second 2 hr, after the injection of thiamylal sodium. The signals recorded from the toroidal 15 degrees of the retina of the glaucomatous dogs during the second recording were significantly larger than those of the first recording. This difference was found only for the larger (> 48 min of arc/phase) gratings. No significant differences were found between the first and second recordings from the central 15 degrees of glaucomatous dogs, nor at any site in the normal dogs.
使用正常比格犬进行了7次实验，使用患有遗传性青光眼的比格犬进行了21次实验，记录了视网膜对一系列光栅刺激（6 - 768分视角/相位）的电生理反应。以动物的中央凹为中心，分别用15度和30度的视野刺激中央视网膜。每只动物完成两个记录系列，每个记录实验中呈现两种刺激大小。在注射硫喷妥钠后30分钟进行第一次记录，2小时后进行第二次记录。在第二次记录期间，从青光眼犬视网膜15度环形区域记录到的信号明显大于第一次记录。这种差异仅在较大（> 48分视角/相位）的光栅中发现。在青光眼犬中央15度区域的第一次和第二次记录之间，以及正常犬的任何部位，均未发现显著差异。
