Meddings J B, Sutherland L R, Byles N I, Wallace J L
Gastrointestinal Research Group, University of Calgary, Alberta, Canada.
Gastroenterology. 1993 Jun;104(6):1619-26. doi: 10.1016/0016-5085(93)90637-r.
Nonsteroidal anti-inflammatory agents (NSAIDs) commonly cause asymptomatic gastroduodenal damage that may be clinically severe. At present the only method to determine the presence or absence of such damage is by invasive techniques such as endoscopy. Because distal small intestinal damage can be noninvasively detected with oral permeability tests, the hypothesis that gastroduodenal damage could be detected using similar methods was examined in the present study.
Animal data are presented suggesting that sucrose represents an ideal probe molecule to detect increased gastroduodenal permeability in a site-specific manner. With gastroduodenal damage, caused by either ethanol or NSAIDs, sucrose permeability is increased. Furthermore, because sucrose is rapidly degraded within the small intestine, this probe does not detect small intestinal damage, making it specific for the upper gastrointestinal tract. Finally, a pilot study in humans is presented to show the use of this technique in evaluating human gastric permeability.
Sucrose represents a novel permeability probe with specificity for damage of the upper gastrointestinal tract. In animals and humans it appears useful to noninvasively detect gastroduodenal injury caused by several agents.
非甾体抗炎药（NSAIDs）常导致无症状的胃十二指肠损伤，而这种损伤在临床上可能很严重。目前，确定此类损伤是否存在的唯一方法是通过诸如内窥镜检查等侵入性技术。由于远端小肠损伤可以通过口服通透性试验进行非侵入性检测，因此在本研究中检验了使用类似方法检测胃十二指肠损伤的假设。
呈现的动物数据表明，蔗糖是一种理想的探针分子，能够以位点特异性方式检测胃十二指肠通透性增加。在由乙醇或NSAIDs引起的胃十二指肠损伤中，蔗糖通透性增加。此外，由于蔗糖在小肠内迅速降解，该探针不会检测到小肠损伤，使其对上消化道具有特异性。最后，展示了一项在人体中的初步研究，以说明该技术在评估人体胃通透性方面的应用。
蔗糖是一种对上消化道损伤具有特异性的新型通透性探针。在动物和人类中，它似乎有助于非侵入性检测由多种因素引起的胃十二指肠损伤。
