Bhogate B M, Samuel A M, Ramanathan P
Radiation Medicine Centre, B.A.R.C., Parel, Bombay, India.
Indian J Cancer. 1993 Mar;30(1):5-9.
Eighty-Six patients of neuroblastoma ranging in age from four months to 15 years were studied with 99m Tc-MDP for total skeletal survey over a period of seven years (1983-1990). The diagnosis of neuroblastoma was based on bone marrow examination, FNAC, lymph node biopsy, histopathology. Bone imaging was performed three hrs. after intravenous administration of 99m Tc-MDP. Out of 86 patients, 45 patients had positive bone scan showing osseous concentration in 122 sites and extraosseous concentration in 34 sites. Seven patients had liver metastases. None of these liver metastases showed concentration of MDP. Fourteen patients underwent surgery for the primary tumour at the time of bone scanning. Ten patients were studied at the time of follow up, of which four patients showed good response as bony metastases were not demonstrated on bone scintigraphy and X-rays. In conclusion, bone scan is an useful test in neuroblastoma in delineating the bony metastases and also in assessing the efficacy of chemotherapy in these patients.
在七年（1983 - 1990年）的时间里，对86例年龄在4个月至15岁之间的神经母细胞瘤患者进行了99m锝-亚甲基二膦酸盐（99m Tc-MDP）全身骨骼扫描研究。神经母细胞瘤的诊断基于骨髓检查、细针穿刺抽吸活检（FNAC）、淋巴结活检及组织病理学检查。静脉注射99m Tc-MDP三小时后进行骨显像。86例患者中，45例骨扫描呈阳性，显示骨内浓聚122处，骨外浓聚34处。7例有肝转移。这些肝转移灶均未显示MDP浓聚。14例患者在骨扫描时接受了原发肿瘤手术。10例患者在随访时接受研究，其中4例显示良好反应，骨闪烁显像和X线检查均未发现骨转移。总之，骨扫描在神经母细胞瘤中是一项有用的检查，可用于描绘骨转移情况，也可评估这些患者化疗的疗效。
