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沙眼衣原体Mip样蛋白是一种脂蛋白。

The Chlamydia trachomatis Mip-like protein is a lipoprotein.

作者信息

Lundemose A G, Rouch D A, Penn C W, Pearce J H

机构信息

Microbial Molecular Genetics and Cell Biology Group, School of Biological Sciences, University of Birmingham, United Kingdom.

出版信息

J Bacteriol. 1993 Jun;175(11):3669-71. doi: 10.1128/jb.175.11.3669-3671.1993.

DOI:10.1128/jb.175.11.3669-3671.1993
PMID:8501072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC204771/
Abstract

The Mip-like protein of Chlamydia trachomatis is similar to the Mip protein of Legionella pneumophila and may be equally important for the initiation of intracellular infection. This article presents data which identify the chlamydial Mip-like protein as a lipoprotein. The amino acid sequence of the Mip-like protein contains a signal peptidase II recognition sequence, as is seen in procaryotic lipoproteins. Palmitic acid was incorporated into the recombinant chlamydial Mip-like protein. Globomycin, known to inhibit signal peptidase II, inhibited processing of the recombinant Mip-like protein. Labelling of chlamydial organisms with palmitic acid revealed incorporation into the native Mip-like protein.

摘要

沙眼衣原体的Mip样蛋白与嗜肺军团菌的Mip蛋白相似，可能对细胞内感染的起始同样重要。本文提供的数据确定了衣原体Mip样蛋白为一种脂蛋白。Mip样蛋白的氨基酸序列包含一个信号肽酶II识别序列，这在原核脂蛋白中可见。棕榈酸被整合到重组衣原体Mip样蛋白中。已知抑制信号肽酶II的球霉素抑制了重组Mip样蛋白的加工。用棕榈酸标记衣原体生物体显示其被整合到天然Mip样蛋白中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb4/204771/fdb2d0a381b8/jbacter00053-0436-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb4/204771/64cf5c1cd6c8/jbacter00053-0436-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb4/204771/f6123cb8a4c4/jbacter00053-0436-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb4/204771/fdb2d0a381b8/jbacter00053-0436-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb4/204771/64cf5c1cd6c8/jbacter00053-0436-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb4/204771/f6123cb8a4c4/jbacter00053-0436-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb4/204771/fdb2d0a381b8/jbacter00053-0436-c.jpg

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