球霉素对前脂蛋白信号肽酶的抑制作用。
Inhibition of prolipoprotein signal peptidase by globomycin.
作者信息
Dev I K, Harvey R J, Ray P H
出版信息
J Biol Chem. 1985 May 25;260(10):5891-4.
PMID:3888977
Abstract
Globomycin inhibits the prolipoprotein-specific signal peptidase activity by binding to the enzyme in a noncompetitive manner (Ki = 36 nM). The Km of prolipoprotein signal peptidase for the prolipoprotein substrate is 6 (+/- 1) microM.
摘要
球霉素通过以非竞争性方式（Ki = 36 nM）与该酶结合来抑制前脂蛋白特异性信号肽酶的活性。前脂蛋白信号肽酶作用于前脂蛋白底物的Km为6（±1）微摩尔。
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