Resch H, Libanati C, Farley S, Bettica P, Schulz E, Baylink D J
Department of Medicine, Loma Linda University, California.
J Clin Endocrinol Metab. 1993 Jun;76(6):1622-4. doi: 10.1210/jcem.76.6.8501171.
We measured the spinal bone density (SBD) and femoral condyle bone density (FCD) in normal and osteoporotic females (n = 219) both before and during fluoride therapy. SBD and FCD in untreated osteoporotics were significantly lower (P < 0.05) than those in the age-matched controls. SBD and FCD were correlated in the untreated (r = 0.62; P < 0.0001) as well as in the fluoride-treated osteoporotics (r = 0.42; P < 0.0001). SBD and FCD were significantly increased (P < 0.05) in response to fluoride therapy. The average rates of increase in FCD and SBD were similar (1.3 +/- 1.3 vs. 1.24 +/- 1.4 mg/cc.month). We conclude that the osteogenic action of fluoride is not limited to the axial skeleton. An increase in trabecular bone density also occurs at peripheral weight-bearing sites such as the femoral condyle.
我们在接受氟化物治疗之前和治疗期间，测量了正常女性和骨质疏松女性（n = 219）的脊柱骨密度（SBD）和股骨髁骨密度（FCD）。未经治疗的骨质疏松患者的SBD和FCD显著低于年龄匹配的对照组（P < 0.05）。未经治疗的骨质疏松患者以及接受氟化物治疗的骨质疏松患者中，SBD和FCD均呈正相关（未经治疗组：r = 0.62；P < 0.0001；接受氟化物治疗组：r = 0.42；P < 0.0001）。氟化物治疗后，SBD和FCD显著增加（P < 0.05）。FCD和SBD的平均增加速率相似（分别为1.3±1.3与1.24±1.4mg/cc·月）。我们得出结论，氟化物的成骨作用不仅限于中轴骨骼。在诸如股骨髁等外周承重部位，小梁骨密度也会增加。
