Lange R, Johannson G, Engel W
Institut für Humangenetik der Universität, Göttingen, Germany.
Hum Reprod. 1993 Apr;8(4):572-4. doi: 10.1093/oxfordjournals.humrep.a138098.
Human fertility problems may be due to chromosomal aberrations in one or both partners. In couples asking for in-vitro fertilization (IVF) the question arises as to whether chromosomal analysis is necessary. We analysed the karyotypes of 72 couples attending our clinic for IVF. Normal chromosomes were found in 131 individuals. One male was found to be a carrier of a Robertsonian translocation t(14q;21q), a second male had a reciprocal translocation t(2;4)(q14;p15) and 11 females exhibited sex chromosome mosaicism. A single cell aberration was demonstrated in 26% (38/144) of all individuals studied. These results clearly show that chromosomal analysis should be performed in couples asking for IVF.
人类生育问题可能是由于一方或双方伴侣的染色体畸变所致。在寻求体外受精（IVF）的夫妇中，就会出现是否有必要进行染色体分析的问题。我们分析了到我们诊所接受IVF治疗的72对夫妇的核型。在131名个体中发现染色体正常。一名男性被发现是罗伯逊易位t(14q;21q)的携带者，另一名男性有相互易位t(2;4)(q14;p15)，11名女性表现出性染色体嵌合现象。在所有研究个体中，26%（38/144）出现了单细胞畸变。这些结果清楚地表明，对于寻求IVF治疗的夫妇，应该进行染色体分析。
