Limaye A P, Ottesen E A, Kumaraswami V, Abrams J S, Regunathan J, Vijayasekaran V, Jayaraman K, Nutman T B
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
J Infect Dis. 1993 Jun;167(6):1396-400. doi: 10.1093/infdis/167.6.1396.
Peripheral blood eosinophil counts and serum levels and in vitro production of eosinophilopoietic cytokines were assessed before and at frequent intervals after diethylcarbamazine treatment of Bancroftian filariasis. Eosinophil counts peaked at day 7 after the start of treatment (359% +/- 118% of pretreatment levels) and declined to pretreatment levels by day 17. Serum interleukin (IL)-5, undetectable in 14 of 15 patients before treatment, rose sharply but transiently, with peak levels (32 +/- 7 pg/mL) 2 days after diethylcarbamazine treatment. Granulocyte-macrophage colony-stimulating factor and IL-3 were not detectable in serum at any time. In vitro mitogen-induced IL-5 levels decreased significantly in 7 of 9 patients 3 days after treatment when serum IL-5 was at near-peak levels. By day 10 IL-5 values increased in 8 of 9 patients compared with treatment values (P < .02). These data define the temporal relation between serum IL-5 levels and the subsequent development of eosinophilia and suggest that lymphocytes are the source of IL-5.
在乙胺嗪治疗班氏丝虫病之前及治疗后定期评估外周血嗜酸性粒细胞计数、血清水平及嗜酸性粒细胞生成细胞因子的体外产生情况。嗜酸性粒细胞计数在治疗开始后第7天达到峰值（为治疗前水平的359%±118%），并在第17天降至治疗前水平。血清白细胞介素（IL）-5在15例患者中有14例在治疗前检测不到，在乙胺嗪治疗后急剧但短暂升高，峰值水平（32±7 pg/mL）出现在治疗后2天。粒细胞-巨噬细胞集落刺激因子和IL-3在血清中任何时候均检测不到。9例患者中有7例在治疗后3天血清IL-5接近峰值水平时，体外有丝分裂原诱导的IL-5水平显著下降。到第10天，9例患者中有8例的IL-5值相对于治疗时的值升高（P<.02）。这些数据确定了血清IL-5水平与随后嗜酸性粒细胞增多之间的时间关系，并提示淋巴细胞是IL-5的来源。
