Willerford D M, Bwayo J J, Hensel M, Emonyi W, Plummer F A, Ngugi E N, Nagelkerke N, Gallatin W M, Kreiss J
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle.
J Infect Dis. 1993 Jun;167(6):1414-7. doi: 10.1093/infdis/167.6.1414.
To determine the frequency and duration of antibody-negative human immunodeficiency virus (HIV) infection among heterosexually exposed African women, 56 HIV-seronegative female prostitutes in Nairobi were studied. Polymerase chain reaction (PCR) was used to detect HIV DNA in peripheral blood at enrollment, and women were followed prospectively with serologic testing to determine HIV seroincidence. Six women (11%) were infected with HIV by PCR criteria at enrollment. Seroconversion occurred in 5 of these subjects within 1-12 months, while the sixth remained seronegative when last evaluated at 5 months. The cumulative annual seroconversion rate in the entire cohort was 38%. Using maximum likelihood analysis, the mean interval between HIV infection and seroconversion was estimated to be between 3 and 4 months, similar to that described for homosexual men and blood product recipients in the United States. Prolonged HIV infection in the absence of antibodies appears to be uncommon in this setting.
为确定异性接触感染的非洲女性中抗体阴性的人类免疫缺陷病毒（HIV）感染的频率和持续时间，对内罗毕56名HIV血清学阴性的女性性工作者进行了研究。在入组时采用聚合酶链反应（PCR）检测外周血中的HIV DNA，并对这些女性进行前瞻性血清学检测以确定HIV血清阳转率。根据PCR标准，有6名女性（11%）在入组时感染了HIV。其中5名受试者在1至12个月内发生了血清阳转，而第6名女性在5个月最后一次评估时仍为血清学阴性。整个队列的累积年血清阳转率为38%。使用最大似然分析，估计HIV感染与血清阳转之间的平均间隔为3至4个月，这与美国同性恋男性和血液制品接受者的情况相似。在这种情况下，无抗体的长时间HIV感染似乎并不常见。
