Mishell D R
Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles.
J Reprod Med. 1993 Apr;38(4):250-9.
Recurrent spontaneous abortion affects about 0.5% of women. The causes of recurrent abortion are fetal and maternal. Most fetal causes are genetic or chromosomal abnormalities. Most maternal causes are congenital or acquired uterine abnormalities. Controversy exists regarding the possible etiology of immunologic factors and lupus anticoagulant activity as causes of recurrent abortion. Performance of histocompatibility locus antigen typing and immunotherapy do not appear to be cost effective or necessary in couples with recurrent abortion. The use of treatment for the presence of lupus anticoagulant or anticardiolipin antibodies has not been found to be superior to no treatment and must be regarded as investigational.
复发性自然流产影响约0.5%的女性。复发性流产的原因包括胎儿和母体因素。大多数胎儿因素是遗传或染色体异常。大多数母体因素是先天性或后天性子宫异常。关于免疫因素和狼疮抗凝物活性作为复发性流产病因的可能机制存在争议。对于复发性流产的夫妇，进行组织相容性位点抗原分型和免疫治疗似乎既不具有成本效益也没有必要。对于存在狼疮抗凝物或抗心磷脂抗体的情况，使用治疗方法并未被发现优于不治疗，因此必须将其视为试验性的。
