Edmonds S E, Blake D R, Morris C J, Winyard P G
Bone and Joint Research Unit, London Hospital Medical College, UK.
J Rheumatol Suppl. 1993 Apr;37:26-31.
The rheumatoid joint is hypoxic. The loss of the physiologic defense mechanism, reflex muscle inhibition, allows the generation of high intraarticular pressures, particularly during exercise. Hypoxia alters the biochemistry of the synovium and encourages the production of reactive oxygen species (ROS) on reperfusion of blood. In excess, ROS damage tissues, and the products of oxidative damage are detectable in rheumatoid synovial fluid. In addition to damaging proteins, carbohydrates and lipids, cellular and structural damage also occurs.
类风湿关节处于缺氧状态。生理防御机制——反射性肌肉抑制的丧失，使得关节内压力升高，尤其是在运动期间。缺氧改变了滑膜的生物化学性质，并促使血液再灌注时活性氧（ROS）的产生。过量的ROS会损害组织，并且在类风湿性滑液中可检测到氧化损伤的产物。除了损害蛋白质、碳水化合物和脂质外，细胞和结构也会受到损伤。
