慢性滑膜炎是再灌注损伤的一个例子吗？
Is chronic synovitis an example of reperfusion injury?
作者信息
Woodruff T, Blake D R, Freeman J, Andrews F J, Salt P, Lunec J
出版信息
Ann Rheum Dis. 1986 Jul;45(7):608-11. doi: 10.1136/ard.45.7.608.
Abstract
In an attempt to define why the joint synovial cavity is prone to develop persistent synovial inflammation we show that hypoxia is induced by pressure changes caused by exercise in the presence of an inflammatory effusion. On resting 'reperfusion injury' may take place. The biochemistry of reperfusion injury has only recently been defined and perhaps surprisingly for an insult that has hypoxia as its central ingredient involves the subsequent production of oxygen derived free radical species. We apply the reaction sequences that are believed to occur during hypoxic/reperfusion injury to the joint synovial cavity and, on the basis of reported 'in vivo' observations, suggest novel therapeutic approaches that we believe are applicable to the treatment of persistent synovial inflammation.
摘要
为了明确为什么关节滑膜腔容易发生持续性滑膜炎，我们发现，在存在炎性积液的情况下，运动引起的压力变化会导致缺氧。在休息时可能会发生“再灌注损伤”。再灌注损伤的生物化学机制直到最近才被确定，也许令人惊讶的是，对于一种以缺氧为核心因素的损伤，其涉及随后产生氧衍生的自由基。我们将据信在缺氧/再灌注损伤期间发生的反应序列应用于关节滑膜腔，并根据已报道的“体内”观察结果，提出我们认为适用于治疗持续性滑膜炎的新治疗方法。
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