Zaki A, Natarajan N, Mettlin C J
Department of Medical Statistics, Medical Research Institute, Alexandria, Egypt.
J Surg Oncol. 1993 Jun;53(2):110-2. doi: 10.1002/jso.2930530212.
This study included 11,111 cases with confirmed primary brain tumors reported by 679 different hospitals in the United States in 1980 and in 1985. The combinations of symptoms and signs in relation to the site of the brain tumors, supratentorial vs infratentorial, were studied. Only one symptom was present in 32.9% and 26.7% of cases with supratentorial and infratentorial tumors. No neurologic sign was detected at the time of diagnosis in 20% and 14.6% of cases with supratentorial and infratentorial tumors, respectively. Considering the clinical stage at diagnosis, no neurologic sign was detected in 21.4% of patients presenting in stages I and II: compared with 11.5% in those presenting in late clinical stages (III & IV). The study confirmed the importance of meticulous history taking for early referral for diagnosis of brain tumors.
该研究纳入了1980年和1985年美国679家不同医院报告的11111例确诊原发性脑肿瘤病例。研究了与脑肿瘤部位相关的症状和体征组合，即幕上肿瘤与幕下肿瘤。幕上肿瘤和幕下肿瘤病例中分别有32.9%和26.7%仅出现一种症状。幕上肿瘤和幕下肿瘤病例在诊断时分别有20%和14.6%未检测到神经系统体征。考虑到诊断时的临床分期，I期和II期就诊患者中有21.4%未检测到神经系统体征，而临床晚期（III期和IV期）就诊患者中这一比例为11.5%。该研究证实了详细询问病史对于早期转诊以诊断脑肿瘤的重要性。
