Gordon G S, Wallace S J, Neal J W
Department of Child Health, University Hospital of Wales, Heath Park, Cardiff.
Arch Dis Child. 1995 Oct;73(4):345-7. doi: 10.1136/adc.73.4.345.
Between 1979 and 1994, 21 children (nine females, 12 males) with intracranial tumours diagnosed before the age of 2 years (range 2-23 months) were treated at the University Hospital of Wales. The commonest presenting symptoms were vomiting (n = 9) and unsteadiness (n = 8); the commonest presenting sign was enlarged occipitofrontal circumference (> 97th centile in 16 and > 90th centile in a further two). In five cases with signs of raised intracranial pressure, meningitis was the clinical diagnosis, and a lumbar puncture was performed. For cases with long delays in diagnosis, multiple other disorders had been considered and the significance of head enlargement had not been recognised. In very early childhood, intracranial tumours are uncommon and can mimic other disorders, especially meningitis. Early neuroimaging is advised when a child presents with recent onset of neurological symptoms and a disproportionately large head.
1979年至1994年间，威尔士大学医院对21名2岁前（年龄范围为2至23个月）被诊断出患有颅内肿瘤的儿童（9名女性，12名男性）进行了治疗。最常见的首发症状是呕吐（n = 9）和步态不稳（n = 8）；最常见的体征是枕额周长增大（16例大于第97百分位数，另外2例大于第90百分位数）。在5例有颅内压升高体征的病例中，临床诊断为脑膜炎，并进行了腰椎穿刺。对于诊断延误较长的病例，曾考虑过多种其他疾病，而头颅增大的意义未被认识到。在幼儿期早期，颅内肿瘤并不常见，且可类似于其他疾病，尤其是脑膜炎。当儿童出现近期发作的神经系统症状且头部不成比例地增大时，建议早期进行神经影像学检查。
