Qi A S, Zheng X, Du C Y, An B S
Department of Physics, Beijing Normal University, P.R. China.
J Theor Biol. 1993 Mar 7;161(1):1-12. doi: 10.1006/jtbi.1993.1035.
A cellular automaton model describing immune system surveillance against cancer is furnished. In formulating the model, we have taken into account the microscopic mechanisms of cancerous growth, such as the proliferation of cancer cells, the cytotoxic behaviors of the immune system, the mechanical pressure inside the tumor and so forth. The model may describe the Gompertz growth of a cancer. The results are in agreement with experimental observations. The influences of the proliferation rate of cancer cells, the cytotoxic rate and other relevant factors affecting the Gompertz growth are studied.
提供了一个描述免疫系统对癌症监测的细胞自动机模型。在构建该模型时,我们考虑了癌症生长的微观机制,如癌细胞的增殖、免疫系统的细胞毒性行为、肿瘤内部的机械压力等。该模型可以描述癌症的戈姆珀茨生长。结果与实验观察结果一致。研究了癌细胞增殖率、细胞毒性率和其他影响戈姆珀茨生长的相关因素的影响。