Vasseur-Cognet M, Lane M D
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Curr Opin Genet Dev. 1993 Apr;3(2):238-45. doi: 10.1016/0959-437x(93)90029-o.
The differentiation of preadipocytes into adipocytes in culture is accompanied by the coordinate transcriptional activation of adipose-specific genes. Recent studies have identified cis-acting elements that are involved in activating (or derepressing) the transcription of many of these genes during differentiation. The identification of key trans-acting nuclear factors that interact with certain of these elements makes it possible to formulate models for the regulatory network governing the adipogenic differentiation program.
在培养过程中，前脂肪细胞向脂肪细胞的分化伴随着脂肪特异性基因的协同转录激活。最近的研究已经确定了一些顺式作用元件，它们在分化过程中参与激活（或去抑制）许多此类基因的转录。与其中某些元件相互作用的关键反式作用核因子的鉴定，使得构建控制脂肪生成分化程序的调控网络模型成为可能。
