Zech P, Pozet N, Carreras-Berges L
Nouv Presse Med. 1977 Apr;6(13):1121-4.
Forty patients suffering from idiopathic oedema were studied. The disturbance in water excretion is characterised by a delay in excretion of a water load (20 ml/kg body weight), an inability to decrease urinary osmolarity below 137 mOsm/1 standing (normal: 60 mOsm +/- 25) and an inability to increase free water clearance: 2.36 +/- 2 ml/mn/1. 73 m2 (normal value: 6.8 ml/mn/1.73 m2) in the upright position. This problem of water excretion related to orthostasis defines and characterises the syndrome, the clinical picture of which is well known. The disturbance suggest a fault in the regulation of anti-diuretic hormone whilst the aldosteronism often described would seem to be inconstant and secondary to diuretic therapy too often prescribed without supervision.
对40例特发性水肿患者进行了研究。水排泄障碍的特征为水负荷（20ml/kg体重）排泄延迟、站立时尿渗透压不能降至137mOsm/1以下（正常：60mOsm±25）以及自由水清除率不能增加：立位时为2.36±2ml/分钟/1.73m2（正常值：6.8ml/分钟/1.73m2）。这种与直立性有关的水排泄问题定义并表征了该综合征，其临床表现众所周知。这种障碍提示抗利尿激素调节存在缺陷，而经常描述的醛固酮增多症似乎并不恒定，且往往继发于未经监督的频繁利尿治疗。
