Temin H M
McArdle Laboratory, Madison, WI 53706.
Proc Natl Acad Sci U S A. 1993 May 15;90(10):4419-20. doi: 10.1073/pnas.90.10.4419.
Human immunodeficiency virus type 1 (HIV-1) is a more complex retrovirus, coding for several accessory proteins in addition to the structural proteins (Gag, Pol, and Env) that are found in all retroviruses. More complex retroviruses have not been isolated from birds, and simpler retroviruses have not been isolated from humans. However, the proviruses of many endogenous simpler retroviruses are present in the human genome. These observations suggest that humans can mount a successful protective response against simpler retroviruses, whereas birds cannot. Thus, humans might be able to mount a successful protective response to infection with a simpler HIV-1. As a model, a simpler bovine leukemia virus which is capable of replicating has been constructed; a simpler HIV-1 could be constructed in a similar fashion. I suggest that such a simpler HIV-1 would be a safe and effective vaccine against HIV-1.
1型人类免疫缺陷病毒（HIV-1）是一种更为复杂的逆转录病毒，除了所有逆转录病毒都具有的结构蛋白（Gag、Pol和Env）外，还编码几种辅助蛋白。尚未从鸟类中分离出更复杂的逆转录病毒，也未从人类中分离出更简单的逆转录病毒。然而，人类基因组中存在许多内源性更简单逆转录病毒的前病毒。这些观察结果表明，人类能够对更简单的逆转录病毒产生成功的保护性反应，而鸟类则不能。因此，人类也许能够对感染更简单的HIV-1产生成功的保护性反应。作为一个模型，已经构建了一种能够复制的更简单的牛白血病病毒；可以以类似的方式构建一种更简单的HIV-1。我认为这样一种更简单的HIV-1将是一种安全有效的抗HIV-1疫苗。
