Visualization of ultraviolet light-induced thymine dimers in DNA by immunoelectron microscopy.
作者信息
Udono M U, Hori M, Hirayama M, Yoshida H, Suematsu T, Suematsu T, Mori T, Matsunaga T, Mizuno T, Nikaido O
机构信息
Department of Dermatology, Nagasaki University School of Medicine, Japan.
出版信息
Photochem Photobiol. 1993 Apr;57(4):752-4. doi: 10.1111/j.1751-1097.1993.tb02949.x.
Abstract
To see the damage of DNA due to ultraviolet-B more distinctly, immunoelectron microscopic studies using a monoclonal antibody against cyclobutane-type thymine dimers were performed. As a result, we could detect the existence of thymine dimers on human genomic DNA and pUC18 plasmid DNA visually. This technique can be useful to locate the photoproducts formed on DNA.
摘要
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