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[新生儿家族性良性惊厥]

[Neonatal familial benign convulsions].

作者信息

Mamí C, Tortorella G, Manganaro R, Gemelli M

机构信息

Istituto di Clinica Pediatrica e Neuropsichiatria Infantile, Università di Messina, Italia.

出版信息

Arch Fr Pediatr. 1993 Jan;50(1):31-3.

PMID:8507136
Abstract

BACKGROUND

Some neonatal benign convulsions are genetic in origin, with a dominant mode of inheritance.

CASE REPORT

A girl was placed on continuous EEG recording from her 2d day of life because of her family history. The first clonic seizures occurred on the 4th day; they appeared again on the 6th day and became prolonged with an abnormal EEG pattern. The seizures were well controlled with phenobarbital, that was gradually discontinued when the child was 3 months old. Seizures occurred again when she was 4 months old and were again controlled with phenobarbital. Her father had had neonatal convulsions which were not well analysed. Her brother also had clonic seizures at the 4th day of life; they disappeared after 1 month. Her sister suffered from clonic seizures when she was 3 days old, and these became prolonged. She was given phenobarbital until she was 1 year old. She developed benign rolandic epilepsy at the age of 10 years.

CONCLUSION

This family suffers from neonatal familial benign convulsions and rolandic epilepsy. The frequency of neonatal familial benign epilepsy is probably under-estimated.

摘要

背景

一些新生儿良性惊厥起源于遗传,呈显性遗传模式。

病例报告

一名女孩因家族病史,自出生第2天起接受连续脑电图记录。首次阵挛性发作于第4天出现;第6天再次发作,并伴有异常脑电图模式且发作时间延长。惊厥用苯巴比妥控制良好,孩子3个月大时逐渐停药。4个月大时再次发作,再次用苯巴比妥控制。她的父亲曾有新生儿惊厥,但未得到充分分析。她的哥哥在出生第4天也有阵挛性发作;1个月后消失。她的姐姐出生3天时出现阵挛性发作,且发作时间延长。她服用苯巴比妥直至1岁。她10岁时患良性中央回癫痫。

结论

这个家族患有新生儿家族性良性惊厥和中央回癫痫。新生儿家族性良性癫痫的发病率可能被低估了。

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