Hiltunen J K, Filppula S A, Häyrinen H M, Koivuranta K T, Hakkola E H
Department of Medical Biochemistry, University of Oulu, Finland.
Biochimie. 1993;75(3-4):175-82. doi: 10.1016/0300-9084(93)90075-4.
Peroxisomes have been shown to play an important role in the oxidative degradation of (poly)unsaturated fatty acids, and contain the enzyme activities needed for the metabolism of double bonds of unsaturated fatty acids in connection with this physiological function. Our understanding of the metabolic pathways and enzyme activities involved in the degradation of unsaturated acyl-CoAs has undergone a re-evaluation recently, and though many open questions still remain significant progress has been made, especially concerning the reactions metabolizing double bonds. The enzyme activities to be discussed here are 2,4-dienoyl-CoA reductase; 3/2-enoyl-CoA isomerase; 2-enoyl-CoA hydratase 2; 5-enoyl-CoA reductase and 3,5/2,4-dienoyl-CoA isomerase. Some of these activities are integral parts of the multifunctional proteins of beta-oxidation systems, which must also be taken into account in this context.
过氧化物酶体已被证明在（多）不饱和脂肪酸的氧化降解中发挥重要作用，并且含有与这种生理功能相关的不饱和脂肪酸双键代谢所需的酶活性。最近，我们对参与不饱和酰基辅酶A降解的代谢途径和酶活性的理解经历了重新评估，尽管仍有许多未解决的问题，但已经取得了重大进展，特别是在代谢双键的反应方面。这里要讨论的酶活性包括2,4-二烯酰辅酶A还原酶；3/2-烯酰辅酶A异构酶；2-烯酰辅酶A水合酶2；5-烯酰辅酶A还原酶和3,5/2,4-二烯酰辅酶A异构酶。其中一些活性是β-氧化系统多功能蛋白的组成部分，在这种情况下也必须予以考虑。
