泰勒氏鼠脑脊髓炎病毒神经毒力的嵌合cDNA研究。
Chimeric cDNA studies of Theiler's murine encephalomyelitis virus neurovirulence.
作者信息
Zhang L, Senkowski A, Shim B, Roos R P
机构信息
Department of Neurology/MC2030, University of Chicago Medical Center, Illinois 60637.
出版信息
J Virol. 1993 Jul;67(7):4404-8. doi: 10.1128/JVI.67.7.4404-4408.1993.
Abstract
Strain GDVII and other members of the GDVII subgroup of Theiler's murine encephalomyelitis virus are highly neurovirulent and rapidly fatal, while strain DA and other members of the TO subgroup produce a chronic, demyelinating disease. GDVII/DA chimeric cDNA studies suggest that a major neurovirulence determinant is within the GDVII 1B through 1D capsid protein coding region, although the additional presence of upstream GDVII sequences, including the 5' untranslated region, contributes to full neurovirulence. Our studies indicate that there are limitations in precisely delineating neurovirulence determinants with chimeric cDNAs between evolutionarily diverged viruses, such as GDVII and DA.
摘要
泰勒氏小鼠脑脊髓炎病毒GDVII株及GDVII亚组的其他成员具有高度神经毒性且致死迅速，而DA株及TO亚组的其他成员则引发一种慢性脱髓鞘疾病。GDVII/DA嵌合cDNA研究表明，主要的神经毒性决定因素位于GDVII的衣壳蛋白编码区1B至1D内，尽管上游GDVII序列（包括5'非翻译区）的额外存在有助于实现完全神经毒性。我们的研究表明，在用进化上差异较大的病毒（如GDVII和DA）之间的嵌合cDNA精确描绘神经毒性决定因素方面存在局限性。
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本文引用的文献
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Detection of tissue culture-adapted Theiler's virus RNA in spinal cord white matter cells throughout infection.在整个感染过程中检测脊髓白质细胞中适应组织培养的泰勒氏病毒RNA。
Infect Immun. 1982 Aug;37(2):763-70. doi: 10.1128/iai.37.2.763-770.1982.
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Biochemical analysis of DA strain of Theiler's murine encephalomyelitis virus obtained directly from acutely infected mouse brain.直接从急性感染小鼠脑内获取的泰勒氏小鼠脑脊髓炎病毒DA株的生化分析。
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Persistent Theiler's murine encephalomyelitis virus infection in mice depends on plaque size.小鼠中持续的泰勒氏鼠脑脊髓炎病毒感染取决于蚀斑大小。
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Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus.泰勒氏小鼠脑脊髓炎病毒DA株的感染性cDNA克隆
J Virol. 1989 Dec;63(12):5492-6. doi: 10.1128/JVI.63.12.5492-5496.1989.
5
Strains from both Theiler's virus subgroups encode a determinant for demyelination.来自泰勒氏病毒两个亚组的毒株都编码一种脱髓鞘决定簇。
J Virol. 1990 Dec;64(12):6345-8. doi: 10.1128/JVI.64.12.6345-6348.1990.
6
Genetic mapping of the ability of Theiler's virus to persist and demyelinate.泰勒氏病毒持续存在和脱髓鞘能力的基因定位。
J Virol. 1990 Sep;64(9):4252-7. doi: 10.1128/JVI.64.9.4252-4257.1990.
7
Neurovirulence determinants of genetically engineered Theiler viruses.基因工程泰勒病毒的神经毒力决定因素。
Proc Natl Acad Sci U S A. 1990 Jun;87(11):4125-9. doi: 10.1073/pnas.87.11.4125.
8
Genomic regions of neurovirulence and attenuation in Theiler murine encephalomyelitis virus.泰勒氏鼠脑脊髓炎病毒的神经毒力和减毒的基因组区域。
Proc Natl Acad Sci U S A. 1990 Feb;87(3):978-82. doi: 10.1073/pnas.87.3.978.
9
Determinants of persistence and demyelination of the DA strain of Theiler's virus are found only in the VP1 gene.泰勒氏病毒DA株持续性感染和脱髓鞘的决定因素仅存在于VP1基因中。
J Virol. 1991 Mar;65(3):1616-8. doi: 10.1128/JVI.65.3.1616-1618.1991.
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J Virol. 1992 Jul;66(7):4508-17. doi: 10.1128/JVI.66.7.4508-4517.1992.
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